U2722DE, MacBook Pro 16", daisy chaining question

@Schmalex  You can’t use a DisplayPort daisy chain with macOS. If you want to run two displays, you have these options:

• Connect both displays directly to the system. There’s no hazard connecting two displays that can supply power to the system simultaneously. The system will only draw the power it wants from the display it chooses.
• Use a Thunderbolt 3 to Dual DisplayPort adapter. This will get both displays running through a single cable from your system, but you won’t have power or USB data connectivity with your system that way.
• Use a Thunderbolt-based dock. CalDigit makes a few that are popular with Mac users. But then you lose most of the benefit of a USB-C display because you’re paying for a separate dock.
• Use Thunderbolt daisy chaining. This gets both displays running from a single output and allows you to use the benefits of a display that supports providing power and USB data connectivity, but it requires native Thunderbolt displays, not USB-C displays, and those are relatively rare. The U2722DE is a USB-C display.

@Schmalex  One other note. Even if macOS did support DisplayPort daisy chaining, your proposed setup wouldn’t have worked. The DP output of the first display would have to be connected to the DP input of the second display. You would not be able to use the USB-C input on the second display for daisy chaining. DVI would only work if you used an active DP to DVI cable/adapter rather than the much more common passive adapter/cable, and that only works for the last display in the daisy chain. That’s sort of a cheat solution though. The official rule is that DisplayPort daisy chains require DisplayPort-based signaling along the entire chain. USB-C for the second display doesn’t work because a regular DisplayPort output doesn’t have the intelligence to set up a USB-C link. USB-C to DP cables/adapters are designed to connect a USB-C output (typically on a system or dock) to a DP input.

I want to do the same thing, a dual display with a macbook pro 16" and 2 U2722DE monitors. I haven't bought the monitors yet. Does your monitor work well with your macbook, no fuzzy text? Did you get a 2nd display set up? Is the monitor bright enough? There isn't a lot of info out there about this, so thank you in advance if you can share your experience. 

@LL825  You'd have to connect each U2722DE directly to the system, without daisy chaining.  In terms of resolution, a 27" 1440p display has a pixel density of 108 ppi, which is within the 100-110 ppi range that Apple uses for standard, non-Retina displays that use 200-220 ppi.  So it's a good match for macOS -- unlike 27" 4K that has a density of 163 ppi, right between the two ranges macOS is optimized for and therefore an equally bad fit with both "modes".  I helped my sister get a U2722DE for her 16" MBP and she's very happy with it.

However, if you intend to use non-Retina external displays and your built-in Retina display simultaneously, you'll have to choose whether macOS should optimize its rendering for the Retina display or the non-Retina displays.  This choice appears under System Preferences > Displays.  For whichever display type you do NOT optimize for, macOS will render content for the non-optimized displays in the mode it's optimizing for, and then use post-render GPU scaling to blow up or shrink down that rendered content as needed to make it fit the pixels of the non-optimized display(s).  As you might expect, that doesn't look quite as good as optimizing for that display, but macOS can't optimize for both simultaneously.  (Neither can Windows, in fact Windows is worse because it will always optimize for the primary display, with no option to optimize for secondary displays if for example you're using one to give a presentation that you want to make sure looks as good as possible.)  But the only solution to that would be to get external displays that have Retina pixel densities, which for 27" would mean 5K displays, but those are of course quite a bit more expensive.  If on the other hand you do NOT intend to use the built-in display and the external displays simultaneously, then everything I just said in this paragraph can be ignored.