x17 R1, turn on S3221QS AMD FreeSync?

Using an AMD video card, the S3221QS supports AMD FreeSync using its DP in port.

So I am confused as to why you think that the x17 R1 Nvidia GPU could turn AMD FreeSync on?

AMD FreeSync monitor can work with NVIDIA video cards when connecting over DisplayPort 1.2 or better.  It won't work over HDMI.  You can enable FreeSync in NVIDIA Control Panel following these steps:

* Updated NVIDIA drivers to the latest ones available. Use the GeForce Experience app for Windows, or else check NVIDIA’s downloads page.
* Restart the PC.
* Check the monitor’ settings menu and verify if FreeSync has been automatically enabled.
* Open the NVIDIA Control Panel app, click on Manage 3D settings, then click the Monitor Technology drop-down and choose G-SYNC Compatible.
* Set the Preferred fresh rate to Highest available, and/or that Vertical sync is set to On. Click Apply to make settings take effect. 
* Note that if you turn on vertical sync in NVIDIA Control Panel, you should disable in-game V-sync settings.
* In the Control Panel’s sidebar, click on Set up G-SYNC (under Display). For your FreeSync monitor, tick the Enable G-SYNC, G-SYNC Compatible and Enable settings for the selected display model checkboxes. When you’re done, click Apply.

Clarification:  FreeSync works on most NVIDIA cards. You'll need a "G-Sync Compatible" monitor connected via DisplayPort 1.2 or later. Compatible NVIDIA cards include GTX 10- or 16-series models, as well as RTX cards from the 20 series onwards.

@Chino de Oro​ Thank you for your time answering.

I was indeed able to get it working by using the USB-C port from the laptop. This was after first trying the thunderbolt port unsuccessfully. Thunderbolt is wired to the integrated chip.

The problem is, on the x17 r1 at least and it seems also on other dell/alienware laptops according to all the things I read online,

Dell/Alienware do not clearly say anywhere which of the diaplay output ports on their laptops are directly wired to the GPU or which ones are wired to the integrated graphics chip. This is important if trying to run an external monitor with gsync. I don't think you can on a port which is wired to the integrated display chip.

I read the user guide and the service guide for the x17 r1. Neither say which ports are wired to the GPU. I can't find any information anywhere which says this, other than a random reddit post from someone with similar issues. Otherwise its trial and error with different cables, which is expensive if you have to buy them.

Thanks again for your time. 

Sometimes, you can find some information listed with notations in Discrete graphics specifications.  But it can not be a straight forward and clear description for port wirings.  On several selected models, Dell uses Hybrid mode or Optimus switchable graphics to send output for both graphics to the same graphics port.  

@Chino de Oro​ Yes, my laptop (x17 r1) has optimus. But from what I can work out, g sync will only work if its on a port which goes direct to the GPU. Even if optimus is diabled in bios.