Installing GPU to E560F-node - What will broke?

Installing GPU to E-series is not supported configuration for VxRail E-nodes, but it is a supported to PowerEdge R640 which the server actually is. NVidia T4  is also supported by VmWare esxi 7.0.3. so there is no reason to system not working. 

BUT.... what will stop not working? Will there be problems on updating the system as there is a HW not supported on E-series while it is in V-series. Will the upgrade stops or just skip updating the fw of GPU or do it as it would on V-series? The support is of course excluded about the GPU..

The case is as one might guess do we have a need for new v-series nodes or can we upgrade the current E-nodes to get extra performance for simulation computing. 

Does anybody have tried this?